Article

Dexamethasone reduces cisplatin-induced ototoxicity by inducing cisplatin resistance through metallothionein-2

2024-03-29

Abstract excerpt

<title>Abstract</title> <p>Purpose Ototoxicity is a common side effect caused by the anticancer drug cisplatin (CDDP), which reduces patient quality of life. One CDDP-resistance mechanism that occurs in recurrent cancers is heavy metal detoxification by metallothionein-2 <italic>(mt2</italic>). Here, we show that in zebrafish larvae, dexamethasone (DEX) reduces CDDP-induced ototoxicity. Methods Transgenic zebra...

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Literature Corpus work: 44932bf9-7451-56d5-a814-2f654c765579
DOI: 10.21203/rs.3.rs-4169473/v1

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