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Evaluation of Cisplatin-Induced Pathology in the Larval Zebrafish Lateral Line

18 Nov 2022

Abstract excerpt

Cisplatin is an effective anticancer agent, but also causes permanent hearing loss by damaging hair cells-the sensory receptors essential for hearing. There is an urgent clinical need to protect cochlear hair cells in patients undergoing cisplatin chemotherapy. The zebrafish lateral line organ contains hair cells and has been frequently used in studies to screen for otoprotective compounds. However, these studies...

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PMID: 36430778
DOI: 10.3390/ijms232214302

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