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Article

Cisplatin-induced ototoxicity in pediatric solid tumors: the role of glutathione S-transferases and megalin genetic polymorphisms.

Journal of pediatric hematology/oncology - 1 May 2013

Choeyprasert Worawut, Sawangpanich Rachchadol, Lertsukprasert Krisna, Udomsubpayakul Umaporn, Songdej Duantida, Unurathapan Usanarat, Pakakasama Samart, Hongeng Suradej

Abstract excerpt

Cisplatin-induced ototoxicity, an important dose-limiting side effect, has proven high interindividual variability. Glutathione S-transferases (GSTs) are isoenzymes involved in cellular detoxification processes. Megalin has been demonstrated to bind aminoglycosides, known to be similar to cisplatin for their ototoxicity. The GSTs and megalin expression is genetically polymorphic, which might be responsible for...

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Identifiers

PMID: 23274376
DOI: 10.1097/MPH.0b013e3182707fc5

Genes

GSTT1
GSTM1

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