Article

<i>In silico</i> transcriptomics identifies FDA-approved drugs and biological pathways for protection against cisplatin-induced hearing loss

2022-01-28

Abstract excerpt

Acquired hearing loss is a major health problem that affects 5-10% of the world population. However, there are no FDA-approved drugs for the treatment or prevention of hearing loss. Employing the Connectivity Map (CMap) that contains >54,000 compounds, we performed an unbiased in silico screen using the transcriptomic profiles of cisplatin-resistant and -sensitive cancer cell lines. Pathway enrichment analysis id...

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Literature Corpus work: d445b43f-d94a-58ea-ba5b-941efd51ac89
DOI: 10.1101/2022.01.26.477836

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