Article

Toll-like receptor 4 is activated by platinum and contributes to cisplatin-induced ototoxicity

2020-06-20

Abstract excerpt

Toll-like receptor 4 (TLR4) is famous for recognizing the bacterial endotoxin lipopolysaccharide (LPS) as its canonical ligand. TLR4 is also activated by other classes of agonist including some Group 9/10 transition metals. Roles for these non-canonical ligands in pathobiology mostly remain obscure, though TLR4 interactions with metals can mediate immune hypersensitivity reactions. In this work, we tested whether...

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Literature Corpus work: 7a7fd73c-905d-5185-8973-e2d0f5536e5f
DOI: 10.1101/2020.06.19.162057

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