Article

Matrix metalloproteinases proteolyze RAB proteins and contribute to cisplatin-induced ototoxicity

2026-03-03

Abstract excerpt

Matrix metalloproteinases (MMPs) are rapidly expressed and activated in response to oxidative stress and contribute to various pathological conditions. Cisplatin is a highly effective chemotherapeutic agent; however, its clinical use is limited by its associated permanent hearing loss (ototoxicity). While cispwlatin-induced oxidative stress and inner ear cell death are well-established, the contribution of MMPs re...

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Literature Corpus work: 1fc1d0c4-00a6-54c2-b04e-6b1b58a5b46f
DOI: 10.64898/2026.02.28.708770

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