Human OCT2 variant c.808G>T confers protection effect against cisplatin-induced ototoxicity.

doi:10.2217/pgs.14.182

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Article

Human OCT2 variant c.808G>T confers protection effect against cisplatin-induced ototoxicity.

Pharmacogenomics - 1 Jan 2015

Lanvers-Kaminsky Claudia, Sprowl Jason A, Malath Ingrid, Deuster Dirk, Eveslage Maria, Schlatter Eberhard, Mathijssen Ron Hj, Boos Joachim, Jürgens Heribert, Am Zehnhoff-Dinnesen Antionette G, Sparreboom Alex, Ciarimboli Giuliano

Abstract excerpt

AIM: Assuming that genetic variants of the SLC22A2 and SLC31A1 transporter affect patients' susceptibility to cisplatin-induced ototoxicity, we compared the distribution of 11 SLC22A2 variants and the SLC31A1 variant rs10981694 between patients with and without cisplatin-induced ototoxicity. PATIENTS & METHODS: Genotyping was performed in 64 pediatric patients and significant findings were re-evaluated in 66...

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PMID: 25823781
DOI: 10.2217/pgs.14.182
PMCID: PMC4865798

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