Article

A novel Golgi-associated Vangl2 translational variant required for PCP regulation in vertebrates

2020-10-20

Abstract excerpt

First described in Drosophila melanogaster , planar cell polarity (PCP) is a developmental process essential for embryogenesis and development of polarized structures in Metazoans. This signaling pathway involves a set of evolutionarily conserved genes encoding transmembrane (Vangl, Frizzled, Celsr) and cytoplasmic (Prickle, Dishevelled) molecules. Vangl2 is of major importance in embryonic development as illustr...

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Literature Corpus work: 3352a1a7-f4ad-544d-ac6b-ed27666e4773
DOI: 10.1101/2020.10.20.347385

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