Article

Single-Cell Transcriptomic Analysis Reveals Two Molecularly and Clinically Distinct Subtypes of Intrahepatic Cholangiocarcinoma

2021-06-25

Abstract excerpt

<title>Abstract</title> <p>Intrahepatic cholangiocarcinoma (iCCA) is a highly heterogeneous cancer with limited understanding of its classification and tumor microenvironment. Here, we performed single-cell RNA sequencing on 144,878 cells from 14 pairs of iCCA tumors and non-tumor liver tissues. We found that S100P and SPP1 are two reliable markers for iCCA perihilar large duct type (iCCA<sup>phl</sup>) and perip...

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Literature Corpus work: 82ca403d-dd9f-5d62-9f12-4f2f8b4de35b
DOI: 10.21203/rs.3.rs-641386/v1

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