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Article

Deep immune profiling of intrahepatic cholangiocarcinoma with CODEX multiplexed imaging.

Hepatology communications - 1 Mar 2025

Baretti Marina, Shekhar Soumya, Sahai Vaibhav, Shu Daniel, Howe Kathryn, Gunchick Valerie, Assarzadegan Naziheh, Kartalia Emma, Zhu Qingfeng, Hallab Elsa, Sheth-Shah Archit, Kondo Aya, Azad Nilofer S, Yarchoan Mark

Abstract excerpt

BACKGROUND: Intrahepatic cholangiocarcinoma (iCCA) may be genomically subclassified by the presence of potentially actionable molecular aberrations, of which pathogenic alterations in isocitrate dehydrogenase (IDH)1 and fibroblast growth factor receptor (FGFR)2 are the most frequently observed. The impact of these molecular alterations on the tumor immune microenvironment remains incompletely understood. METHODS:...

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Identifiers

PMID: 39969434
DOI: 10.1097/HC9.0000000000000632
PMCID: PMC11841852

Genes

FGFR2
IDH1
CD4

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