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BMP-2 generates a functional bone marrow niche by inducing the differentiation of local mesenchymal cells into CAR cells

13 Mar 2025

Abstract excerpt

ABSTRACT: Ectopic bone marrow (eBM) holds tremendous potential as an artificial organ, serving not only in stem cell transplantation therapies but also as a controlled experimental system for analyzing cellular dynamics and interactions between cells and the matrix during the formation, maintenance, and aging of BM. Although bone morphogenetic protein-2 (BMP-2) has been reported to induce eBM formation, it...

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PMID: 40080674
DOI: 10.1182/bloodadvances.2024014062

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