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The HSC niche concept has turned 31

1 Apr 2010

Abstract excerpt

The hematopoietic stem cell (HSC) niche is currently defined as the specific microenvironment in the bone marrow (BM) which anatomically harbors HSCs and governs their fate. It plays a pivotal role in regulating the survival and self-renewal ability of HSCs, protecting them from exhaustion while preventing their excessive proliferation. Many different stromal cell types have been proposed as putative constituents...

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PMID: 20392212
DOI: 10.1111/j.1749-6632.2009.05223.x

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