Article
Cathepsin Z is a conserved susceptibility factor underlying tuberculosis severity.
PLoS biology - 1 Sept 2025
Meade Rachel K, Adefisayo Oyindamola O, Gontijo Marco T P, Harris Summer J, Pyle Charlie J, Wilburn Kaley M, Ecker Alwyn M V, Hughes Erika J, Garcia Paloma D, Ivie Joshua, McHenry Michael L, Benchek Penelope H, Mayanja-Kizza Harriet, Neff Jadee L, Ko Dennis C, Stout Jason E, Stein Catherine M, Hawn Thomas R, Tobin David M, Smith Clare M
Abstract excerpt
Tuberculosis (TB) outcomes vary widely, from asymptomatic infection to mortality, yet most animal models do not recapitulate human phenotypic and genotypic variation. The genetically diverse Collaborative Cross mouse panel models distinct facets of TB disease that occur in humans and allows identification of genomic loci underlying clinical outcomes. We previously mapped a TB susceptibility locus on mouse...
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