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Article

Susceptibility loci affecting ERBB2/neu-induced mammary tumorigenesis in mice.

Genes, chromosomes & cancer - 1 Jul 2012

Quan Lei, Dittmar Ashley, Zhou Yuxun, Hutson Alan, Stassen Alphons P M, Demant Peter

Abstract excerpt

Twenty percent of breast cancers exhibit amplification or overexpression of ERBB2/neu and a poor prognosis. As the susceptibility genes controlling ERBB2 tumorgenesis are unknown, in a genetic mapping project we crossed transgenic mice expressing the neu oncogene under control of MMTV promoter with recombinant congenic (RC) strains, which provided a high mapping power. RC strains differed considerably in tumor...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22419448
DOI: 10.1002/gcc.21949

Genes

ERBB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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