Article

Early life sleep disruption potentiates lasting sex-specific changes in behavior in genetically vulnerable Shank3 heterozygous autism model mice

2021-09-24

Abstract excerpt

<h4>Background: </h4> Patients with autism spectrum disorder (ASD) experience high rates of sleep disruption beginning early in life, however the developmental consequences of this disruption are not understood. We examined sleep behavior and the consequences of sleep disruption in developing mice bearing C-terminal truncation mutation in the high-confidence ASD risk gene SHANK3 (Shank3ΔC). We hypothesized that sl...

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Literature Corpus work: bf1da382-abf0-5881-975d-e9600cbef77e
DOI: 10.1101/2021.09.23.461518

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