Back to search

Article

Costimulation of TLR8 responses by CXCL4 in Human Monocytes Mediated by TBK1-IRF5 Signaling and Epigenomic Remodeling

2021-10-04

Abstract excerpt

<title>Abstract</title> <p>CXCL4 regulates responses of immune cells to endosomal TLRs and has been implicated in the pathogenesis of inflammatory and fibrotic diseases. However, mechanisms by which CXCL4 modulates TLR responses, and its functions in monocytes/macrophages, are still unclear. Here we report that CXCL4 changes the profile of the TLR8 response in human monocytes by selectively and dramatically ampli...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
445a507d-6074-5efc-85b3-bea761266ff7
DOI
10.21203/rs.3.rs-945383/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Costimulation of TLR8 responses by CXCL4 in Human Monocytes Mediated by TBK1-IRF5 Signaling and Epigenomic RemodelingDOI 10.21203/rs.3.rs-945383/v1
Costimulation of TLR8 responses by CXCL4 in Human Monocytes Mediated by TBK1-IRF5 Signaling and Epigenomic RemodelingSemantic proximity
CXCL4 signaling and gene induction in human monocytes involve a TLR4 response divergent from LPSSemantic proximity
CXCL4 links inflammation and fibrosis through transcriptional and epigenetic reprogramming of monocyte-derived cellsSemantic proximity
Epigenetic regulation of Leukocyte associated immunoglobulin-like receptors 1 and 2 by interferon signaling in macrophages and T cellsSemantic proximity
IL-10 Targets IRFs to Suppress IFN and Inflammatory Response Genes by Epigenetic MechanismsSemantic proximity
Role of IRF8 in immune cells functions, protection against infections, and susceptibility to inflammatory diseases.Semantic proximity
Chemokines form nanoparticles with DNA and can superinduce TLR-driven immune inflammationSemantic proximity
Epigenetic Regulation of Inflammatory NF-κB Target Genes by IFN-γ via IRF1Semantic proximity
T Cell-Intrinsic IRF5 Regulates T Cell Signaling, Migration, and Differentiation and Promotes Intestinal Inflammation.Semantic proximity
The Transcription Factor IRF8 Activates Integrin-Mediated TGF-β Signaling and Promotes NeuroinflammationSemantic proximity
Primary 1,25-Dihydroxyvitamin D3 Response of the Interleukin 8 Gene Cluster in Human Monocyte- and Macrophage-Like CellsSemantic proximity
Monocyte Subsets with High Osteoclastogenic Potential and Their Epigenetic Regulation Orchestrated by IRF8Semantic proximity
Select a neighboring publication to make it the new centre.