Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Chemokines form nanoparticles with DNA and can superinduce TLR-driven immune inflammation

31 May 2022

Abstract excerpt

Chemokines control the migratory patterns and positioning of immune cells to organize immune responses to pathogens. However, many chemokines have been associated with systemic autoimmune diseases that have chronic IFN signatures. We report that a series of chemokines, including CXCL4, CXCL10, CXCL12, and CCL5, can superinduce type I IFN (IFN-I) by TLR9-activated plasmacytoid DCs (pDCs), independently of their...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chemokine receptors and signaling
Share to Immunotherapy and Immune Responses
Share to T-cell and B-cell Immunology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35640018
DOI: 10.1084/jem.20212142

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Chemokines form nanoparticles with DNA and can superinduce TLR-driven immune inflammationPMID 35640018Read ↗

Costimulation of TLR8 responses by CXCL4 in Human Monocytes Mediated by TBK1-IRF5 Signaling and Epigenomic RemodelingSemantic proximity Read ↗

CXCL4 assembles DNA into liquid crystalline complexes to amplify TLR9-mediated interferon-α production in systemic sclerosisSemantic proximity Read ↗

CXCL4 signaling and gene induction in human monocytes involve a TLR4 response divergent from LPSSemantic proximity Read ↗

ChemokinesSemantic proximity Read ↗

Costimulation of TLR8 responses by CXCL4 in Human Monocytes Mediated by TBK1-IRF5 Signaling and Epigenomic RemodelingSemantic proximity Read ↗

Chemokines in health and diseaseSemantic proximity Read ↗

Touch of ChemokinesSemantic proximity Read ↗

CXCL10 Chemokine: A Critical Player in RNA and DNA Viral InfectionsSemantic proximity Read ↗

Role of chemokine systems in cancer and inflammatory diseasesSemantic proximity Read ↗

Chemokines, their receptors and human disease: the good, the bad and the itchy.Semantic proximity Read ↗

Chemokines in homeostasis and diseasesSemantic proximity Read ↗

CXCL4 Exposure Potentiates TLR-Driven Polarization of Human Monocyte-Derived Dendritic Cells and Increases Stimulation of T Cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.