Article

CXCL4 signaling and gene induction in human monocytes involve a TLR4 response divergent from LPS

2022-10-26

Abstract excerpt

The chemokine CXCL4 activates myeloid cells and contributes to the pathogenesis of inflammatory and fibrotic diseases. One mechanism of CXCL4 action is binding of nucleic acids to promote their internalization and activation of endosomal TLRs. However, the signaling pathways and receptors that mediate myeloid cell responses to CXCL4 alone are not well characterized. Here, we report that in primary human monocytes,...

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Literature Corpus work: 307fee3f-4ab8-5ab1-9200-e401f4d806de
DOI: 10.1101/2022.10.26.513860

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