Article
NAD+ Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair.
Cell metabolism - 11 Oct 2016
Fang Evandro Fei, Kassahun Henok, Croteau Deborah L, Scheibye-Knudsen Morten, Marosi Krisztina, Lu Huiming, Shamanna Raghavendra A, Kalyanasundaram Sumana, Bollineni Ravi Chand, Wilson Mark A, Iser Wendy B, Wollman Bradley N, Morevati Marya, Li Jun, Kerr Jesse S, Lu Qiping, Waltz Tyler B, Tian Jane, Sinclair David A, Mattson Mark P, Nilsen Hilde, Bohr Vilhelm A
Abstract excerpt
Ataxia telangiectasia (A-T) is a rare autosomal recessive disease characterized by progressive neurodegeneration and cerebellar ataxia. A-T is causally linked to defects in ATM, a master regulator of the response to and repair of DNA double-strand breaks. The molecular basis of cerebellar atrophy and neurodegeneration in A-T patients is unclear. Here we report and examine the significance of increased PARylation,...
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