Mitochondrial CSA and CSB: protein interactions and protection from ageing associated DNA mutations.

Abstract excerpt

Cockayne syndrome (CS) is a rare autosomal recessive disease with progeroid symptoms, which is caused mainly by mutations in the CS genes CSA and CSB. Although the relevance of mitochondria in the aging process is known for several decades, research focused primarily on the role of the CS proteins in the nucleus. Recently, however, mitochondrial contribution to aging-associated symptoms of CS has been described....

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