Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Differential expression and functionality of TRPA1 protein genetic variants in conditions of thermal stimulation.

The Journal of biological chemistry - 3 Aug 2012

May Denisa, Baastrup Jonas, Nientit Maria Raphaela, Binder Andreas, Schünke Michael, Baron Ralf, Cascorbi Ingolf

Abstract excerpt

The role of genetic modifications of the TRPA1 receptor has been well documented in inflammatory and neuropathic pain. We recently reported that the E179K variant of TRPA1 appears to be crucial for the generation of paradoxical heat sensation in pain patients. Here, we describe the consequences of the single amino acid exchange at position 179 in the ankyrin repeat 4 of human TRPA1. TRPA1 wild type Lys-179...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Calcium Channels

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Line

Share to Nerve Tissue Proteins

Share to Sequence Homology, Amino Acid

Share to Temperature

Share to Transient Receptor Potential Channels

Share to TRPA1 Cation Channel

Source

Open in PubMed Open full text

Identifiers

PMID: 22665484
DOI: 10.1074/jbc.M112.341776
PMCID: PMC3411051

Genes

TRPA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Differential expression and functionality of TRPA1 protein genetic variants in conditions of thermal stimulation.PMID 22665484Read ↗

Molecular Mechanism of Hyperactivation Conferred by a Truncated TRPA1 Disease Mutant Suggests New Gating InsightsSemantic proximity Read ↗

TRPA1 gene variants hurting our feelings.Semantic proximity Read ↗

A novel TRPA1 gain-of-function variant associated with painful sensory neuropathy acts through a PIP2 gating mechanism.Semantic proximity Read ↗

Human TRPM8 and TRPA1 pain channels, including a gene variant with increased sensitivity to agonists (TRPA1 R797T), exhibit differential regulation by SRC-tyrosine kinase inhibitor.Semantic proximity Read ↗

Essential role for the putative S6 inner pore region in the activation gating of the human TRPA1 channel.Semantic proximity Read ↗

TRPA1.Semantic proximity Read ↗

Disentangling Schwann Cell and Neuronal TRPA1 Function in Mouse Models of Familial Episodic Pain SyndromeSemantic proximity Read ↗

Proinflammatory mediators modulate the heat-activated ion channel TRPV1 via the scaffolding protein AKAP79/150.Semantic proximity Read ↗

Reduced TRPM8 expression underpins reduced migraine risk and attenuated cold pain sensation in humans.Semantic proximity Read ↗

Why individual thermo sensation and pain perception varies? Clue of disruptive mutations in TRPVs from 2504 human genome data.Semantic proximity Read ↗

Mutations of TRPM8 channels: Unraveling the molecular basis of activation by cold and ligands.Semantic proximity Read ↗

Mapping the binding site of TRPV1 on AKAP79: implications for inflammatory hyperalgesia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.