Article
A Neuronal-specific Mammalian Homolog of theDrosophilaRetinal Degeneration B Gene with Expression Restricted to the Retina and Dentate Gyrus
1 Sept 1999
Abstract excerpt
Mutations in the Drosophila retinal degeneration B (rdgB) gene cause a rapid loss of the electrophysiological light response and subsequent light-enhanced photoreceptor degeneration. The rdgB gene encodes a protein with an N-terminal phosphatidylinositol transfer protein domain, a large C-terminal segment, and several hydrophobic regions thought to multiply span the subrhabdomeric cisternal membrane. A mammalian...