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Article

Protein motions during catalysis by dihydrofolate reductases.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 29 Aug 2006

Allemann Rudolf K, Evans Rhiannon M, Tey Lai-hock, Maglia Giovanni, Pang Jiayun, Rodriguez Robert, Shrimpton Paul J, Swanwick Richard S

Abstract excerpt

Dihydrofolate reductase (DHFR) maintains the intracellular pool of tetrahydrofolate through catalysis of hydrogen transfer from reduced nicotinamide adenine dinucleotide to 7,8-dihydrofolate. We report results for pre-steady-state kinetic studies of the temperature dependence of the rates and the hydrogen/deuterium-kinetic isotope effects for the reactions catalysed by the enzymes from the mesophilic Escherichia...

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Source

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Identifiers

PMID: 16873119
DOI: 10.1098/rstb.2006.1865
PMCID: PMC1647303

Genes

DHFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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