Article

Elevated ferritin as a companion biomarker of myeloid-driven inflammation in RNP/Sm co-positive, treatment-resistant SLE endotype

2026-02-14

Abstract excerpt

<h4>Background</h4> The profound molecular heterogeneity of SLE remains a fundamental barrier to therapeutic progress. <h4>Methods</h4> We integrated clinical and multi-omic profiling, including transcriptomics, autoantigen microarrays, proteomics, and flow cytometry, across three randomised trials (BEAT-Lupus, CALIBRATE, ACCESS) and two observational cohorts to identify distinct lupus endotypes. <h4>Findings</h...

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Literature Corpus work: 44266c7f-aee0-500e-bfd8-60f63c91bf2c
DOI: 10.64898/2026.02.12.705402

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