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Article

Rational attenuation of RNA viruses with zinc finger antiviral protein

8 Sept 2022

Abstract excerpt

Attenuation of a virulent virus is a proven approach for generating vaccines but can be unpredictable. For example, synonymous recoding of viral genomes can attenuate replication but sometimes results in pleiotropic effects that confound rational vaccine design. To enable specific, conditional attenuation of viruses, we examined target RNA features that enable zinc finger antiviral protein (ZAP) function. ZAP...

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PMID: 36075961
DOI: 10.1038/s41564-022-01223-8

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