Article

A single-cell and spatial atlas of autopsy tissues reveals pathology and cellular targets of SARS-CoV-2

2021-02-25

Abstract excerpt

The SARS-CoV-2 pandemic has caused over 1 million deaths globally, mostly due to acute lung injury and acute respiratory distress syndrome, or direct complications resulting in multiple-organ failures. Little is known about the host tissue immune and cellular responses associated with COVID-19 infection, symptoms, and lethality. To address this, we collected tissues from 11 organs during the clinical autopsy of 17...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f0a5f791-484d-5ec5-8992-bf50a6cca722
DOI: 10.1101/2021.02.25.430130

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A single-cell and spatial atlas of autopsy tissues reveals pathology and cellular targets of SARS-CoV-2DOI 10.1101/2021.02.25.430130Read

Cellular and molecular heterogeneities and signatures, and pathological trajectories of fatal COVID-19 lungs defined by spatial single-cell transcriptome analysisSemantic proximity Read

System-wide transcriptome damage and tissue identity loss in COVID-19 patientsSemantic proximity Read

From COVID to fibrosis: lessons from single-cell analyses of the human lungSemantic proximity Read

A single-nucleus and spatial transcriptomic atlas of the COVID-19 liver reveals topological, functional, and regenerative organ disruption in patientsSemantic proximity Read

Adult Stem Cell-derived Complete Lung Organoid Models Emulate Lung Disease in COVID-19Semantic proximity Read

Integrated histopathology, spatial and single cell transcriptomics resolve cellular drivers of early and late alveolar damage in COVID-19Semantic proximity Read

Impaired local intrinsic immunity to SARS-CoV-2 infection in severe COVID-19Semantic proximity Read

Adult stem cell-derived complete lung organoid models emulate lung disease in COVID-19Semantic proximity Read

Spatially resolved single-cell atlas of the lung in fatal Covid19 in an African population reveals a distinct cellular signature and an interferon gamma dominated responseSemantic proximity Read

Molecular and Immune Signatures, and Pathological Trajectories of Fatal Covid-19 Lungs Defined by in Situ Spatial Single-Cell Transcriptome AnalysisSemantic proximity Read

A single-cell transcriptomic landscape of the lungs of patients with COVID-19Semantic proximity Read

Dissecting the common and compartment-specific features of COVID-19 severity in the lung and periphery with single-cell resolutionSemantic proximity Read