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Article

The aging transcriptome and cellular landscape of the human lung in relation to SARS-CoV-2

4 Jan 2021

Abstract excerpt

Abstract Age is a major risk factor for severe coronavirus disease-2019 (COVID-19). Here, we interrogate the transcriptional features and cellular landscape of the aging human lung. By intersecting these age-associated changes with experimental data on SARS-CoV-2, we identify several factors that may contribute to the heightened severity of COVID-19 in older populations. The aging lung is transcriptionally...

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PMID: 33397975
DOI: 10.1038/s41467-020-20323-9

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