Article

RhoV Promotes Proliferation, Migration, and MAPK Activation in Pancreatic Ductal Adenocarcinoma

2025-09-16

Abstract excerpt

<h4>Background and Aims</h4> Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy characterized by diagnosis at advanced stages, limited therapeutic options, and frequent resistance to therapies. Although oncogenic KRAS mutations are central drivers of PDAC, alternative pathways indisputably contribute to its tumorigenesis and progression. RhoV, a member of the Rho family of small GTPases, has be...

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Literature Corpus work: a564054c-573f-54ab-98c9-b2e39812a542
DOI: 10.1101/2025.09.10.672939

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