Article

Deep tissue infection by an invasive human fungal pathogen requires novel lipid-based suppression of the IL-17 response

2022-02-08

Abstract excerpt

Candida albicans is the most common cause of human fungal infection, but the mechanisms of invasive pathogenesis remain poorly defined. Here we identify an unexpected mechanism: lipid-mediated immunosuppression. Through forward genetics, we found that C. albicans secretes a lipase, Lip2, that is critical for invasive disease. Murine infection with C. albicans strains that lack Lip2 display an exaggerated host IL...

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Literature Corpus work: 60a10bfb-8d85-576a-aef1-1ba2aea36495
DOI: 10.1101/2022.02.07.479457

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Deep tissue infection by an invasive human fungal pathogen requires novel lipid-based suppression of the IL-17 responseDOI 10.1101/2022.02.07.479457Read

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