Article

Proteomic analysis reveals complex interactions between PERK/ISR and MAPK1 in translational control in a phenotypic toxin model of Parkinson’s disease expressing PINTAC peptides

2024-12-17

Abstract excerpt

In a proteomics investigation of a Parkinson’s disease [PD] cell model, a panel of 7 proprietary PINTAC peptides deployed in an in vitro phenotypic screen in SH-SY5Y cells treated with 6-OHDA identified 2 shorter variants of PERK protein kinase. One of the PERK variants, which is SUMOylated, associates in vitro with phosphorylated EIF2 alpha and its ubiquitinated isoforms, which also involves another PERK substr...

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Literature Corpus work: 43be9b1b-1b15-5e2c-9c7a-fd4d56aa5a28
DOI: 10.1101/2024.12.14.628501

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