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Article

Tau reduction prevents disease in a mouse model of Dravet syndrome.

Annals of neurology - 1 Sept 2014

Gheyara Ania L, Ponnusamy Ravikumar, Djukic Biljana, Craft Ryan J, Ho Kaitlyn, Guo Weikun, Finucane Mariel M, Sanchez Pascal E, Mucke Lennart

Abstract excerpt

OBJECTIVE: Reducing levels of the microtubule-associated protein tau has shown promise as a potential treatment strategy for diseases with secondary epileptic features such as Alzheimer disease. We wanted to determine whether tau reduction may also be of benefit in intractable genetic epilepsies. METHODS: We studied a mouse model of Dravet syndrome, a severe childhood epilepsy caused by mutations in the human...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25042160
DOI: 10.1002/ana.24230
PMCID: PMC4338764

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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