Article

Matrix nucleotide homeostasis couples energetic state to mitochondrial translation

2026-06-06

Abstract excerpt

Mitochondrial protein synthesis must adapt to fluctuations in organellar energetic state to sustain oxidative phosphorylation and cellular homeostasis, yet the mechanisms coupling mitochondrial bioenergetics to gene expression remain poorly understood. Here, we identify matrix nucleotide phosphorylation potential as a direct metabolic determinant of mitochondrial translation. Using ATP synthase inhibition as an ex...

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Literature Corpus work: 43aa3813-4852-5d21-830f-328c163e4a82
DOI: 10.64898/2026.06.04.730174

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