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OXPHOS Defects Due to mtDNA Mutations: Glutamine to the Rescue!

Cell metabolism - 5 Jun 2018

Chinopoulos Christos

Abstract excerpt

Mutations in mtDNA associated with OXPHOS defects preclude energy harnessing by OXPHOS. The work of Chen et al. (2018) is previewed, reporting flux pathways of glutamine catabolism in mtDNA mutant cells yielding high-energy phosphates through substrate-level phosphorylation and the influence exerted by the severity of OXPHOS impairment.

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PMID: 29874564
DOI: 10.1016/j.cmet.2018.05.010

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