Article

Ribonucleotide synthesis by NME6 fuels mitochondrial gene expression

2022-11-30

Abstract excerpt

Replication and expression of the mitochondrial genome depend on the sufficient supply of nucleotide building blocks to mitochondria. Dysregulated nucleotide metabolism is detrimental to mitochondrial genomes and can result in instability of mitochondrial DNA and inflammation. Here, we report that a mitochondrial nucleoside diphosphate kinase, NME6, supplies mitochondria with ribonucleotides to drive the transcrip...

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Literature Corpus work: fe745eb6-1d88-55ec-83a3-9fd0162736da
DOI: 10.1101/2022.11.29.518352

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