Article
Transient and constitutive repression of cytoplasmic translation signaling in cells with mtDNA mutation.
Cellular and molecular life sciences : CMLS - 1 Feb 2009
Janssen G M C, Schwertman P, Wanga T A T, Tafrechi R S Jahangir, van den Broek P J A, Raap A K
Abstract excerpt
Cytoplasmic translation is under sophisticated control but how cells adapt its rate to constitutive loss of mitochondrial oxidative phosphorylation is unknown. Here we show that translation is repressed in cells with the pathogenic A3243G mtDNA mutation or in mtDNA-less rho(0) cells by at least t...
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