Article

DNA-Directed Assembly of Multivalent Lipid Nanoparticles for Targeted T Cell Gene Delivery

2025-09-09

Abstract excerpt

Lipid nanoparticles (LNPs) are a powerful emerging tool for in vivo T cell engineering with applications ranging from B cell lymphomas to other cancers and autoimmune diseases. Key challenges in designing these therapeutics include achieving both precise cell targeting and efficient mRNA translation. While single-targeted LNPs have been extensively studied, bispecific LNPs have only been briefly explored. Engagem...

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Literature Corpus work: 4398d8c4-ff0c-59e0-93a0-bd34704292a9
DOI: 10.1101/2025.09.04.674323

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