Bispecific antibody targeting of lipid nanoparticles

Abstract excerpt

Lipid nanoparticles (LNP) are the most clinically advanced non-viral gene delivery system. While progress has been made for enhancing delivery, cell specific targeting remains a challenge. Targeting moieties such as antibodies can be chemically-conjugated to LNPs however, this approach is complex and has challenges for scaling up. Here, we developed an approach to generate antibody-conjugated LNPs that utilizes a...

Topics

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• Antibodies, Bispecific
• CAR-T cell therapy research
• Immunotherapy
• Monoclonal and Polyclonal Antibodies Research
• Mutation
• Neoplasms
• Tumor Suppressor Protein p53
• Viral Infectious Diseases and Gene Expression in Insects

Identifiers and source

Literature Corpus work

ae5a99ff-d003-5e77-8a99-e85ee0b80e6c

DOI

10.1101/2024.12.20.629467