Article
Tertiary lymphoid structures improve immunotherapy and survival in melanoma.
Nature - 1 Jan 2020
Cabrita Rita, Lauss Martin, Sanna Adriana, Donia Marco, Skaarup Larsen Mathilde, Mitra Shamik, Johansson Iva, Phung Bengt, Harbst Katja, Vallon-Christersson Johan, van Schoiack Alison, Lövgren Kristina, Warren Sarah, Jirström Karin, Olsson Håkan, Pietras Kristian, Ingvar Christian, Isaksson Karolin, Schadendorf Dirk, Schmidt Henrik, Bastholt Lars, Carneiro Ana, Wargo Jennifer A, Svane Inge Marie, Jönsson Göran
Abstract excerpt
Checkpoint blockade therapies that reactivate tumour-associated T cells can induce durable tumour control and result in the long-term survival of patients with advanced cancers1. Current predictive biomarkers for therapy response include high levels of intratumour immunological activity, a high tumour mutational burden and specific characteristics of the gut microbiota2,3. Although the role of T cells in...
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