Article

Immune organization in sentinel lymph nodes of melanoma patients is prognostic of distant metastases

2024-11-26

Abstract excerpt

Sentinel lymph node (sLN) biopsy is part of melanoma staging, as involved LNs indicate a higher risk of recurrence. However, how the sLN is shaped by the tumor and reciprocally affects metastatic progression is poorly understood. Here, we mapped immune organization in involved and non-involved sLNs of 69 melanoma patients using high-resolution spatial proteomics, spatial transcriptomics and deep learning, leveragi...

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Literature Corpus work: c27d96ac-a033-5aeb-9997-bf2f6e5ee3d0
DOI: 10.1101/2024.11.24.625041

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