Article

Myosin light chain proteins cooperatively promote sarcomere growth in fast-twitch muscle

2024-09-19

Abstract excerpt

Muscle becomes stronger by expanding sarcomeres from the cell’s edge to its center. Here we investigate how Mylpf (Myosin Light Chain Phosphorylatable Fast) abundance impacts sarcomere growth. The two zebrafish Mylpf genes ( mylpfa and mylpfb ) are exclusively expressed in fast-twitch muscle, with mylpfa expressed more abundantly than mylpfb . Mutations in both genes cause full mRNA and protein loss, and loss...

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Literature Corpus work: 438c6c0f-edef-5954-96e4-2cb81803cca6
DOI: 10.1101/2024.09.18.613721

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