Article
Myosin light chain proteins cooperatively promote sarcomere growth in fast-twitch muscle.
Nature communications - 4 Jun 2026
Adekeye Tayo E, Hupper Troy E, Easterbrooks Teresa E, Teets Emily M, Tomak Emily A, Waterman Sadie L, Sprague Kailee A, White Angelina, Coffin Maddison L, Tanaka Daniel K, Varga Sabrina M, Soares Mason T, Shepherd Sarah J, Austin Jared D, Krivorotko Dmitrii, Perry Emma S, Amacher Sharon L, Kelley Joshua B, Talbot Jared C
Abstract excerpt
Muscle becomes stronger by expanding sarcomeres from the cell's edge to its center. Here we investigate how Mylpf (Myosin Light Chain Phosphorylatable Fast) abundance impacts sarcomere growth. The two zebrafish Mylpf genes (mylpfa and mylpfb) are exclusively expressed in fast-twitch muscle, with mylpfa expressed more abundantly than mylpfb. Mutations in both genes cause full mRNA and protein loss, and loss of...
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