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Article

A putative molecular-activation switch in the transmembrane domain of erbB2.

Proceedings of the National Academy of Sciences of the United States of America - 10 Dec 2002

Fleishman Sarel J, Schlessinger Joseph, Ben-Tal Nir

Abstract excerpt

Overexpression of the receptor tyrosine kinase (RTK) erbB2 (also designated neu or HER2) was implicated in causing a variety of human cancers, including mammary and ovarian carcinomas. Ligand-induced receptor dimerization is critical for stimulation of the intrinsic protein tyrosine kinase (PTK) of RTKs. It was therefore proposed that PTK activity is stimulated as a result of the reorientation of the cytoplasmic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 12461170
DOI: 10.1073/pnas.252640799
PMCID: PMC138543

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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