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Article

Triptolide suppresses IDH1-mutated malignancy via Nrf2-driven glutathione metabolism.

Proceedings of the National Academy of Sciences of the United States of America - 5 May 2020

Yu Di, Liu Yang, Zhou Yiqiang, Ruiz-Rodado Victor, Larion Mioara, Xu Guowang, Yang Chunzhang

Abstract excerpt

Isocitrate dehydrogenase (IDH) mutation is a common genetic abnormality in human malignancies characterized by remarkable metabolic reprogramming. Our present study demonstrated that IDH1-mutated cells showed elevated levels of reactive oxygen species and higher demands on Nrf2-guided glutathione de novo synthesis. Our findings showed that triptolide, a diterpenoid epoxide from Tripterygium wilfordii, served as a...

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Identifiers

PMID: 32312817
DOI: 10.1073/pnas.1913633117
PMCID: PMC7211987

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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