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Non-coding RNA: A key regulator in the Glutathione-GPX4 pathway of ferroptosis

20 May 2024

Abstract excerpt

Ferroptosis, a form of regulated cell death, has emerged as a crucial process in diverse pathophysiological states, encompassing cancer, neurodegenerative ailments, and ischemia-reperfusion injury. The glutathione (GSH)-dependent lipid peroxidation pathway, chiefly governed by glutathione peroxidase 4 (GPX4), assumes an essential part in driving ferroptosis. GPX4, as the principal orchestrator of ferroptosis, has...

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PMID: 39036600
DOI: 10.1016/j.ncrna.2024.05.007

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