Article

Systematic genome-scale identification of host factors for SARS-CoV-2 infection across models yields a core single gene dependency; <i>ACE2</i>

2021-06-29

Abstract excerpt

<h4>SUMMARY</h4> SARS-CoV-2, depends on host cell components for replication, therefore the identification of virus-host dependencies offers an effective way to elucidate mechanisms involved in viral infection. Such host factors may be necessary for infection and replication of SARS-CoV-2 and, if druggable, presents an attractive strategy for anti-viral therapy. We performed genome wide CRISPR knockout screens in...

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Literature Corpus work: c688995b-ac4c-589d-860d-9195147865e5
DOI: 10.1101/2021.06.28.450244

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