Article

Global siRNA Screen Reveals Critical Human Host Factors of SARS-CoV-2 Multicycle Replication

2024-07-10

Abstract excerpt

Defining the subset of cellular factors governing SARS-CoV-2 replication can provide critical insights into viral pathogenesis and identify targets for host-directed antiviral therapies. While a number of genetic screens have previously reported SARS-CoV-2 host dependency factors, these approaches relied on utilizing pooled genome-scale CRISPR libraries, which are biased towards the discovery of host proteins impa...

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Literature Corpus work: 9548b772-4a66-5b07-a192-1c72cf33fadf
DOI: 10.1101/2024.07.10.602835

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