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Article

Mechanisms for recurrent and complex human genomic rearrangements.

Current opinion in genetics & development - 1 Jun 2012

Liu Pengfei, Carvalho Claudia M B, Hastings P J, Lupski James R

Abstract excerpt

During the last two decades, the importance of human genome copy number variation (CNV) in disease has become widely recognized. However, much is not understood about underlying mechanisms. We show how, although model organism research guides molecular understanding, important insights are gained from study of the wealth of information available in the clinic. We describe progress in explaining nonallelic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22440479
DOI: 10.1016/j.gde.2012.02.012
PMCID: PMC3378805

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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