Article

Integrative genetic and immune cell analysis of plasma proteins in healthy donors identifies novel associations involving primary immune deficiency genes

2021-03-29

Abstract excerpt

Blood plasma proteins play an important role in immune defense against pathogens, including cytokine signaling, the complement system and the acute-phase response. Recent large-scale studies have reported genetic ( i . e . quantitative trait loci, pQTLs) and non-genetic factors, such as age and sex, as major determinants to inter-individual variability in immune response variation. However, the contribution of blo...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 42c774e5-b54e-521e-ad08-b1bf78ac03b6
DOI: 10.1101/2021.03.26.21254301

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Integrative genetic and immune cell analysis of plasma proteins in healthy donors identifies novel associations involving primary immune deficiency genesDOI 10.1101/2021.03.26.21254301Read

Integrative genetic and immune cell analysis of plasma proteins in healthy donors identifies novel associations involving primary immune deficiency genes.Semantic proximity Read

Plasma proteomic associations with genetics and health in the UK Biobank.Semantic proximity Read

Genetic regulation of the human plasma proteome in 54,306 UK Biobank participantsSemantic proximity Read

Non-linear genetic regulation of the blood plasma proteomeSemantic proximity Read

Systematic discovery of gene-environment interactions underlying the human plasma proteome in UK Biobank.Semantic proximity Read

Consequences of natural perturbations in the human plasma proteomeSemantic proximity Read

Proteomic analysis of 92 circulating proteins and their effects in cardiometabolic diseasesSemantic proximity Read

Systematic discovery of gene-environment interactions underlying the human plasma proteome in UK BiobankSemantic proximity Read

Mapping biological influences on the human plasma proteome beyond the genomeSemantic proximity Read

Beyond the classical plasma secretome: genetic architecture and disease associations of the expanded human plasma proteome in 13,445 EuropeansSemantic proximity Read

Sexual Dimorphism, Age, and Fat Mass Are Key Phenotypic Drivers of Proteomic Signatures.Semantic proximity Read