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Article

Integrative genetic and immune cell analysis of plasma proteins in healthy donors identifies novel associations involving primary immune deficiency genes.

Genome medicine - 9 Mar 2022

Caron Barthelemy, Patin Etienne, Rotival Maxime, Charbit Bruno, Albert Matthew L, Quintana-Murci Lluis, Duffy Darragh, Rausell Antonio

Abstract excerpt

BACKGROUND: Blood plasma proteins play an important role in immune defense against pathogens, including cytokine signaling, the complement system, and the acute-phase response. Recent large-scale studies have reported genetic (i.e., protein quantitative trait loci, pQTLs) and non-genetic factors, such as age and sex, as major determinants to inter-individual variability in immune response variation. However, the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 35264221
DOI: 10.1186/s13073-022-01032-y
PMCID: PMC8905727

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