Article

FLIP is essential for oncogenic <i>KRAS-</i> driven lung cancer

2026-08-05

Abstract excerpt

Mutations in KRAS represent the most common oncogenic event in human cancer and occur in approximately 30% of lung adenocarcinomas. The mechanisms by which lung tumours evade apoptosis induced by oncogenic KRAS-driven stress remain incompletely understood. Here, we identify the anti-apoptotic regulator FLIP ( CFLAR ) as a critical dependency in KRAS-mutant lung cancers. We demonstrate that KRAS-mutant human lung...

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Literature Corpus work: 42c3c428-586d-5ce3-b049-831f5d571b7f
DOI: 10.64898/2026.08.04.738686

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